(19)

(11)

EP 1 105 153 A1

(12)

(43) Date of publication: 13.06.2001 Bulletin 2001/24 (21) Application number: 97940746.7 (22) Date of filing: 28.08.1997

(51) International Patent Classification (IPC)7: A61K 39/00, A61K 39/38, A61K 38/08, C12P 21/06, C12P 21/04, C12P 21/08, C12N 15/00, C12N 15/09, C12N 15/63, C12N 15/70, C12N 15/74 (86) International application number: PCT/US9715/394 (87) International publication number: WO 9808/540 (05.03.1998 Gazette 1998/09)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 28.08.1996 US 704159 (71) Applicant: OPHIDIAN PHARMACEUTICALS, INC. Madison, WI 53711 (US)	(72) Inventors: WILLIAMS, James, A. Lincoln, NE 68516 (US) THALLEY, Bruce, S. Madison, WI 53705 (US) (74) Representative: Glawe, Delfs, Moll & Partner  PatentanwälteRothenbaumchaussee 58 20148 Hamburg 20148 Hamburg (DE)