(19)

(11)

EP 1 105 160 A1

(12)

(43) Date of publication: 13.06.2001 Bulletin 2001/24 (21) Application number: 99945126.3 (22) Date of filing: 18.08.1999

(51) International Patent Classification (IPC)7: A61K 39/395, C07H 21/04, A01N 61/00, A01N 37/18, A01N 43/04, C12N 5/00, C12N 15/00 (86) International application number: PCT/US9919/068 (87) International publication number: WO 0010/602 (02.03.2000 Gazette 2000/09)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 18.08.1998 US 96996 P 18.08.1998 US 96997 P (71) Applicant: YALE UNIVERSITY New Haven, CT 06510 (US)

(72) Inventors: XU, Tian Guilford, CT 06437 (US) TAO, Wufan Minneapolis, MN 55455 (US) ST. JOHN, Maie, A., R. Los Angeles, CA 90064 (US) FEI, Xiaolan New Haven, CT 06511 (US) FUKUMOTO, Royd, K. Alea, HI 96701 (US) ZHANG, Sheng New Haven, CT 06511 (US) TURENCHALK, Gregory, S. New Haven, CT 06511 (US) STEWART, Rodney, A. New Haven, CT 06511 (US) (74) Representative: Silveston, Judith et al ABEL & IMRAY20 Red Lion Street London, WC1R 4PQ London, WC1R 4PQ (GB)