(19)

(11)

EP 1 105 164 A2

(12)

(88) Date of publication A3: 11.05.2000 (43) Date of publication: 13.06.2001 Bulletin 2001/24 (21) Application number: 99966745.4 (22) Date of filing: 17.08.1999

(51) International Patent Classification (IPC)7: A61K 51/00, A61M 36/14 (86) International application number: PCT/US9919/011 (87) International publication number: WO 0009/076 (24.02.2000 Gazette 2000/08)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 17.08.1998 US 96803 P (71) Applicant: THOMAS JEFFERSON UNIVERSITY Philadelphia, PA 19107 (US)	(72) Inventor: THAKUR, Madhukar (Mathew), L. Cherry Hill, NJ 08003 (US) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)