(19)

(11)

EP 1 105 400 A1

(12)

(43) Date of publication: 13.06.2001 Bulletin 2001/24 (21) Application number: 99941237.2 (22) Date of filing: 20.08.1999

(51) International Patent Classification (IPC)7: C07F 9/6568, B01J 31/24, C07B 53/00, C07F 17/02, C07F 9/6571 // C07M7:00 (86) International application number: PCT/US9918/932 (87) International publication number: WO 0011/008 (02.03.2000 Gazette 2000/09)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 21.08.1998 US 97473 P 19.08.1999 US 377065 (71) Applicant: THE PENN STATE RESEARCH FOUNDATION University Park, PA 16802-7000 (US)	(72) Inventor: ZHANG, Xumu State College, PA 16803 (US) (74) Representative: HOFFMANN - EITLE  Patent- und RechtsanwälteArabellastrasse 4 81925 München 81925 München (DE)