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(11)

EP 1 105 406 A1

(12)

(43) Date of publication: 13.06.2001 Bulletin 2001/24 (21) Application number: 99941162.2 (22) Date of filing: 13.08.1999

(51) International Patent Classification (IPC)7: C07H 21/04, C07K 14/00, C12N 15/63, C12N 15/85, C12N 15/86 (86) International application number: PCT/US9918/556 (87) International publication number: WO 0009/534 (24.02.2000 Gazette 2000/08)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 14.08.1998 US 96570 P (71) Applicant: Elan Pharmaceuticals, Inc. South San Francisco, CA 94080 (US)	(72) Inventors: FORSAYETH, John, R. San Francisco, CA 94110 (US) ZHAO, Byron, B. Palo Alto, CA 94303 (US) (74) Representative: Lee, Nicholas John et al Kilburn & Strode,20 Red Lion Street London WC1R 4PJ London WC1R 4PJ (GB)