(19)

(11)

EP 1 105 418 A1

(12)

(43) Date of publication: 13.06.2001 Bulletin 2001/24 (21) Application number: 99942152.2 (22) Date of filing: 12.08.1999

(51) International Patent Classification (IPC)7: C07K 14/39, C07K 16/14, C07K 16/26, C12N 1/00, C12N 1/15, C12N 1/19, C12N 5/10, C12N 15/31, C12N 15/63, C12P 21/02, C12Q 1/02, C12Q 1/68, G01N 33/53 (86) International application number: PCT/US9918/402 (87) International publication number: WO 0009/550 (24.02.2000 Gazette 2000/08)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 14.08.1998 US 96609 P 03.02.1999 US 118370 P (71) Applicant: THE RESEARCH FOUNDATION OFSTATE UNIVERSITY OF NEW YORK Albany,New York 12201-0009 (US)	(72) Inventor: DEAN, Neta Setauket, NY 11733 (US) (74) Representative: Grund, Martin, Dr. et al Dr. Volker Vossius,Patentanwaltskanzlei,Holbeinstrasse 5 81679 München 81679 München (DE)