(19)

(11)

EP 1 105 420 A1

(12)

(43) Date of publication: 13.06.2001 Bulletin 2001/24 (21) Application number: 99943903.7 (22) Date of filing: 20.08.1999

(51) International Patent Classification (IPC)7: C07K 14/475, A61K 38/18, A61P 25/00 (86) International application number: PCT/US9919/378 (87) International publication number: WO 0012/553 (09.03.2000 Gazette 2000/10)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 28.08.1998 US 98359 P (71) Applicant: MYELOS CORPORATION San Diego, CA 92121 (US)	(72) Inventors: WRIGHT, David, E. Ramona, CA 92065 (US) O'BRIEN, John, S. La Jolla, CA 92037 (US) (74) Representative: De Clercq, Ann et al De Clercq, Brants & Partners cv.,Edgard Gevaertdreef 10a 9830 Sint-Martens-Latem 9830 Sint-Martens-Latem (BE)