(19)

(11)

EP 1 105 461 A2

(12)

(88) Date of publication A3: 08.06.2000 (43) Date of publication: 13.06.2001 Bulletin 2001/24 (21) Application number: 99942193.6 (22) Date of filing: 13.08.1999

(51) International Patent Classification (IPC)7: C12N 5/06, C12N 15/85, C07K 14/475, C12N 15/66, C12N 15/86, G01N 33/53 (86) International application number: PCT/US9918/525 (87) International publication number: WO 0009/676 (24.02.2000 Gazette 2000/08)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 14.08.1998 US 96630 P (71) Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY PasadenaCalifornia 91125 (US)	(72) Inventors: ANDERSON, David, J. Pasadena, CA 91001 (US) LO, Li-Ching Arcadia, CA 91006 (US) (74) Representative: Walton, Seán Malcolm et al MEWBURN ELLIS,York House,23 Kingsway London WC2B 6HP London WC2B 6HP (GB)