(19)

(11)

EP 1 105 465 A1

(12)

(43) Date of publication: 13.06.2001 Bulletin 2001/24 (21) Application number: 99941986.4 (22) Date of filing: 02.08.1999

(51) International Patent Classification (IPC)7: C12N 5/10, C12N 5/16, C12N 15/12, C12N 15/62, C12N 15/63, C12N 15/64, C07K 14/705 (86) International application number: PCT/US9917/388 (87) International publication number: WO 0008/133 (17.02.2000 Gazette 2000/07)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 06.08.1998 US 95571 P (71) Applicant: MERCK & CO., INC. Rahway, New Jersey 07065 (US)	(72) Inventors: LIU, Qingyun Rahway, NJ 07065 (US) McDONALD, Terrence, P. Rahway, NJ 07065 (US) WANG, Ruiping Rahway, NJ 07065 (US) (74) Representative: Horgan, James Michael Frederic  Merck & Co., Inc.,Terlings Park,Eastwick Road Harlow,Essex CM20 2QR Harlow,Essex CM20 2QR (GB)