(19)

(11)

EP 1 105 472 A2

(12)

(88) Date of publication A3: 08.06.2000 (43) Date of publication: 13.06.2001 Bulletin 2001/24 (21) Application number: 99945053.9 (22) Date of filing: 12.08.1999

(51) International Patent Classification (IPC)7: C12N 15/10, C12Q 1/68 (86) International application number: PCT/US9918/393 (87) International publication number: WO 0009/755 (24.02.2000 Gazette 2000/08)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 12.08.1998 US 96330 P 14.08.1998 US 133934 (71) Applicant: Pangene Corporation Fremont, CA 94538 (US)	(72) Inventors: ZARLING, David Menlo Park, CA 94025 (US) REDDY, Gurucharan Redwood City, CA 94063 (US) PATI, Sushma Los Altos, CA 94024 (US) (74) Representative: Denison, Christopher Marcus et al Mewburn EllisYork House23 Kingsway GB-London WC2B 6HP GB-London WC2B 6HP (GB)