(19)

(11)

EP 1 105 494 A2

(12)

(88) Date of publication A3: 22.06.2000 (43) Date of publication: 13.06.2001 Bulletin 2001/24 (21) Application number: 99944406.0 (22) Date of filing: 16.08.1999

(51) International Patent Classification (IPC)7: C12N 15/31, C07K 14/40, A61K 31/70, A61K 38/16, C07K 16/14, G01N 33/50, C12Q 1/68 (86) International application number: PCT/EP9905/991 (87) International publication number: WO 0009/695 (24.02.2000 Gazette 2000/08)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 14.08.1998 GB 9817796 23.12.1998 EP 98310694 (71) Applicant: JANSSEN PHARMACEUTICA N.V. 2340 Beerse (BE)	(72) Inventors: CONTRERAS, Roland Henri B-9000 Gent (BE) NELISSEN, Bart B-2340 Beerse (BE) DE BACKER, Marianne, Denise B-2340 Beerse (BE) LUYTEN, Walter Herman Maria Louis B-2340 Beerse (BE) VIAENE, Jasmine Elza B-9000 Gent (BE) LOGGHE, Marc George B-9000 Gent (BE) (74) Representative: De Corte, Filip Alois Julia  Janssen Pharmaceutica N.V.Turnhoutseweg 30 2340 Beerse 2340 Beerse (BE)