(19)

(11)

EP 1 105 534 A1

(12)

(43) Date of publication: 13.06.2001 Bulletin 2001/24 (21) Application number: 99942117.5 (22) Date of filing: 11.08.1999

(51) International Patent Classification (IPC)7: C12Q 1/68, C12P 19/34, C07H 21/02, C07H 21/04, G01N 33/566 (86) International application number: PCT/US9918/266 (87) International publication number: WO 0009/752 (24.02.2000 Gazette 2000/08)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 14.08.1998 US 96586 P (71) Applicants: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA Philadelphia,Pennsylvania 19107 (US) THE CHILDREN'S HOSPITAL OF PHILADELPHIA Philadelphia, PA 19104 (US)	(72) Inventors: REBBECK, Timothy, R. Wynnewood, PA 19096 (US) FELIX, Carolyn, A. Ardmore, PA 19003 (US) (74) Representative: Ablett, Graham Keith et al Ablett & Stebbing,Caparo House,101-103 Baker Street London W1M 1FD London W1M 1FD (GB)