(19)

(11)

EP 1 105 538 A2

(12)

(88) Date of publication A3: 24.08.2000 (43) Date of publication: 13.06.2001 Bulletin 2001/24 (21) Application number: 99945051.3 (22) Date of filing: 12.08.1999

(51) International Patent Classification (IPC)7: C12Q 1/68, C12N 15/85, C12N 9/02, C07K 16/40, A61K 39/395, C12N 5/10, A61K 48/00, A61K 31/70, G01N 33/573, A01K 67/027 (86) International application number: PCT/US9918/387 (87) International publication number: WO 0009/754 (24.02.2000 Gazette 2000/08)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 14.08.1998 US 96520 P 05.08.1999 US  (71) Applicant: JOHNSON & JOHNSON CONSUMER COMPANIES, INC. Skillman, NJ 08558 (US)	(72) Inventors: STENN, Kurt Princeton, NJ 08540 (US) PROUTY, Stephen, M. Doylestown, PA 18901 (US) PARIMOO, Satish Bridgewater, NJ 08807 (US) ZHANG, Lin Somerville, NJ 08875 (US) (74) Representative: Fisher, Adrian John  CARPMAELS & RANSFORD43 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)