(19)

(11)

EP 1 107 738 A1

(12)

(43) Date of publication: 20.06.2001 Bulletin 2001/25 (21) Application number: 99968215.6 (22) Date of filing: 26.08.1999

(51) International Patent Classification (IPC)7: A61K 9/16, A61K 9/22, A61K 9/58 (86) International application number: PCT/US9919/575 (87) International publication number: WO 0012/067 (09.03.2000 Gazette 2000/10)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 27.08.1998 US 98154 P (71) Applicant: Bristol-Myers Squibb Company Princeton, NJ 08543-4000 (US)	(72) Inventor: RAYBURN, James, W. Evansville, IN 47720 (US) (74) Representative: Bentz, Jean-Paul et al Cabinet Weinstein,56 A, rue du Faubourg Saint-Honoré 75008 Paris 75008 Paris (FR)