(19)

(11)

EP 1 107 797 A2

(12)

(88) Date of publication A3: 04.05.2000 (43) Date of publication: 20.06.2001 Bulletin 2001/25 (21) Application number: 99945522.3 (22) Date of filing: 27.08.1999

(51) International Patent Classification (IPC)7: A61K 48/00, C07H 21/04 (86) International application number: PCT/US9920/393 (87) International publication number: WO 0012/139 (09.03.2000 Gazette 2000/10)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 27.08.1998 US 98158 P 05.05.1999 US 132684 P (71) Applicant: Quark Biotech, Inc. Pleasanton, CA 94566 (US)	(72) Inventors: FEINSTEIN, Elena Rehovot (IL) EINAT, Paz 74042 Nes-Ziona (IL) SKALITER, Rami 74037 Nes-Ziona (IL) (74) Representative: Wittop Koning, Tom Hugo  Exter Polak & Charlouis B.V.,P.O. Box 3241 2280 GE Rijswijk 2280 GE Rijswijk (NL)