(19)

(11)

EP 1 107 943 A1

(12)

(43) Date of publication: 20.06.2001 Bulletin 2001/25 (21) Application number: 99943937.5 (22) Date of filing: 26.08.1999

(51) International Patent Classification (IPC)7: C07C 211/45, C07C 215/56, C07C 255/50 (86) International application number: PCT/US9919/494 (87) International publication number: WO 0012/461 (09.03.2000 Gazette 2000/10)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 28.08.1998 US 98335 P (71) Applicant: SMITHKLINE BEECHAM CORPORATION PhiladelphiaPennsylvania 19103 (US)	(72) Inventors: LABAW, Clifford, S. Philadelphia, PA 19144 (US) SHILCRAT, Susan, C. Bala Cynwyd, PA 19004 (US) (74) Representative: Connell, Anthony Christopher et al GlaxoSmithKline,Two New Horizons Court Brentford, Middlesex TW8 9EP Brentford, Middlesex TW8 9EP (GB)