(19)
(11) EP 1 107 948 A1

(12)

(43) Date of publication:
20.06.2001 Bulletin 2001/25

(21) Application number: 99943936.7

(22) Date of filing: 26.08.1999
(51) International Patent Classification (IPC)7C07C 273/02, C07C 275/28, C07C 255/49, C07D 213/02, C07D 263/54
(86) International application number:
PCT/US9919/492
(87) International publication number:
WO 0012/468 (09.03.2000 Gazette 2000/10)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

(30) Priority: 28.08.1998 US 98249 P

(71) Applicant: Smithkline Beecham
Philadelphia, PA 19103 (US)

(72) Inventors:
  • BAINE, Neil, H.
    Merion Station, PA 19066 (US)
  • CLARK, William, M., Jr.
    Hamilton Square, NJ 08690 (US)
  • ELDRIDGE, Ann, Marie
    Norristown, PA 19401 (US)

(74) Representative: Connell, Anthony Christopher et al
GlaxoSmithKline,Two New Horizons Court
Brentford, Middlesex TW8 9EP
Brentford, Middlesex TW8 9EP (GB)

   


(54) AN IMPROVED SYNTHESIS OF 3-HYDROXY-4-AMINO-BENZONITRILE