(19)

(11)

EP 1 108 013 A2

(12)

(88) Date of publication A3: 24.08.2000 (43) Date of publication: 20.06.2001 Bulletin 2001/25 (21) Application number: 99942517.6 (22) Date of filing: 26.08.1999

(51) International Patent Classification (IPC)7: C12N 9/64, C07K 14/47, C12N 15/57, C12N 15/12, C12N 5/10, A61K 38/48, A61K 38/17, C07K 16/18, C07K 16/40, C12Q 1/68 (86) International application number: PCT/US9919/615 (87) International publication number: WO 0012/685 (09.03.2000 Gazette 2000/10)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 01.09.1998 US 144952 01.09.1998 US 155194 P (71) Applicant: INCYTE PHARMACEUTICALS, INC. Palo Alto, CA 94304 (US)	(72) Inventors: WALKER, Michael, G. Sunnyvale, CA 94089 (US) VOLKMUTH, Wayne Menlo Park, CA 94025 (US) KLINGLER, Tod, M. San Carlos, CA 94070 (US) (74) Representative: Wright, Simon Mark  Kilburn & Strode30 John Street London WC1N 2DD London WC1N 2DD (GB)