(19)

(11)

EP 1 108 020 A1

(12)

(43) Date of publication: 20.06.2001 Bulletin 2001/25 (21) Application number: 99943113.3 (22) Date of filing: 03.09.1999

(51) International Patent Classification (IPC)7: C12N 15/12, C07K 14/47, C12N 15/63, C12N 5/10, C07K 16/18, G01N 33/68 (86) International application number: PCT/GB9902/909 (87) International publication number: WO 0014/221 (16.03.2000 Gazette 2000/11)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 04.09.1998 GB 9819405 (71) Applicant: SMITHKLINE BEECHAM PLC Brentford,Middlesex TW8 9EP (GB)	(72) Inventors: DUCKWORTH, David M.,SmithKline Beecham Pharm. Harlow,Essex CM19 5AW (GB) EVANS, Joanne, Rachel,SmithKline Beecham Pharm. Harlow,Essex CM19 5AW (GB) (74) Representative: Crump, Julian Richard John  FJ Cleveland,40-43 Chancery Lane London WC2A 1JQ London WC2A 1JQ (GB)