(19)

(11)

EP 1 108 029 A1

(12)

(43) Date of publication: 20.06.2001 Bulletin 2001/25 (21) Application number: 99945458.0 (22) Date of filing: 01.09.1999

(51) International Patent Classification (IPC)7: C12N 15/15, C07K 14/81, C12N 1/21, C12N 5/10, C12N 1/19 (86) International application number: PCT/US9920/202 (87) International publication number: WO 0014/235 (16.03.2000 Gazette 2000/11)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 03.09.1998 US 148092 (71) Applicant: ZymoGenetics Seattle, WA 98102 (US)	(72) Inventor: CONKLIN, Darrell, C. Seattle, WA 98102 (US) (74) Representative: Williams, Richard Andrew Norman et al Hepworth Lawrence Bryer & BizleyMerlin HouseFalconry CourtBakers Lane Epping, Essex CM16 5DQ Epping, Essex CM16 5DQ (GB)