(19)

(11)

EP 1 108 031 A2

(12)

(88) Date of publication A3: 31.08.2000 (43) Date of publication: 20.06.2001 Bulletin 2001/25 (21) Application number: 99943182.8 (22) Date of filing: 02.09.1999

(51) International Patent Classification (IPC)7: C12N 15/29, C12N 15/82, C07K 14/415, G01N 33/53, G01N 33/577, G01N 33/68, C12C 5/00, C12C 1/00 (86) International application number: PCT/IB9901/597 (87) International publication number: WO 0014/237 (16.03.2000 Gazette 2000/11)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL Designated Extension States: AL LT LV MK RO SI (30) Priority: 03.09.1998 US 146703 13.01.1999 US 115756 P (71) Applicants: Vaag, Pia 2800 Lyngby (DK) Bech, Lene Moslskov 2765 Smorum (DK) Cameron-Mills, Varena 2500 Valby (DK) Sorensen, Mikael Blom 1058 Kbh K (DK)	(72) Inventors: Vaag, Pia 2800 Lyngby (DK) Bech, Lene Moslskov 2765 Smorum (DK) Cameron-Mills, Varena 2500 Valby (DK) Sorensen, Mikael Blom 1058 Kbh K (DK) (74) Representative: Mallalieu, Catherine Louise et al D. Young & Co.,21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)