(19)

(11)

EP 1 108 034 A2

(12)

(88) Date of publication A3: 03.08.2000 (43) Date of publication: 20.06.2001 Bulletin 2001/25 (21) Application number: 99946122.1 (22) Date of filing: 03.09.1999

(51) International Patent Classification (IPC)7: C12N 15/31, C12N 15/63, C12N 1/21, C07K 14/255, C07K 16/12, C12N 15/62, C12N 15/74, A61K 39/112 // C12N1:21, C12R1:42 (86) International application number: PCT/EP9906/514 (87) International publication number: WO 0014/240 (16.03.2000 Gazette 2000/11)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 04.09.1998 EP 98116827 (71) Applicant: Creatogen Aktiengesellschaft 86156 Augsburg (DE)	(72) Inventors: HENSEL, Michael D-80639 München (DE) GUZM N, Carlos, Alberto D-38304 Wolfenbüttel (DE) MEDINA, Eva D-38100 Braunschweig (DE) APFEL, Heiko D-86356 Augsburg (DE) HUECK, Christoph D-86159 Augsburg (DE) (74) Representative: Weiss, Wolfgang, Dipl.-Chem. Dr. et al Weickmann & WeickmannPatentanwältePostfach 86 08 20 81635 München 81635 München (DE)