(19)
(11) EP 1 108 036 A1

(12)

(43) Date of publication:
20.06.2001 Bulletin 2001/25

(21) Application number: 99906779.6

(22) Date of filing: 05.02.1999
(51) International Patent Classification (IPC)7: C12N 15/40, C12N 7/01, A61K 39/12, A01K 67/033, A61K 48/00
(86) International application number:
PCT/US9902/598
(87) International publication number:
WO 0014/245 (16.03.2000 Gazette 2000/11)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

(30) Priority: 02.09.1998 US 98981 P

(71) Applicant: THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
Rockville, MD 20752 (US)

(72) Inventors:
  • ZENG, Lingling
    Brooklyn, NY 11214 (US)
  • MARKOFF, Lewis
    Bethesda, MD 20817 (US)

(74) Representative: VOSSIUS & PARTNER 
Siebertstrasse 4
81675 München
81675 München (DE)

   


(54) DENGUE VIRUSES THAT ARE REPLICATION DEFECTIVE IN MOSQUITOS FOR USE AS VACCINES