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(11)

EP 1 108 038 A1

(12)

(43) Date of publication: 20.06.2001 Bulletin 2001/25 (21) Application number: 99943065.5 (22) Date of filing: 27.08.1999

(51) International Patent Classification (IPC)7: C12N 15/53, C12N 9/02, A61K 38/44, A61K 31/70, A61K 48/00, C07K 16/40 (86) International application number: PCT/GB9902/828 (87) International publication number: WO 0012/718 (09.03.2000 Gazette 2000/10)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 27.08.1998 GB 9818756 (71) Applicants: MICROBIOLOGICAL RESEARCH AUTHORITY Salisbury, Wiltshire SP4 0JG (GB) IMPERIAL COLLEGE OF SCIENCE,TECHNOLOGY & MEDICINE London SW7 2AZ (GB)

(72) Inventors: GORRINGE, Andrew R.Microbio. Res. Authority SalisburyWiltshire SP4 0JG (GB) KROLL, John SimonImperial College School of Med. London W2 1PG (GB) LANGFORD, Paul RichardImp. College School Med. London W2 1PG (GB) ROBINSON, AndrewMicrobiological Research Authorit SalisburyWiltshire SP4 0JG (GB) (74) Representative: Schlich, George William et al Mathys & Squire100 Gray's Inn Road London WC1X 8AL London WC1X 8AL (GB)