(19)

(11)

EP 1 108 048 A1

(12)

(43) Date of publication: 20.06.2001 Bulletin 2001/25 (21) Application number: 99943838.5 (22) Date of filing: 23.08.1999

(51) International Patent Classification (IPC)7: C12N 15/86, A61K 48/00 (86) International application number: PCT/US9919/162 (87) International publication number: WO 0011/202 (02.03.2000 Gazette 2000/09)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 24.08.1998 US 97653 P (71) Applicant: GENZYME CORPORATION Framingham,Massachusetts 01701 (US)	(72) Inventors: WADSWORTH, Samuel, C. Shrewsbury, MA 01545 (US) O'RIORDAN, Catherine, E. Jamaica Plains, MA 02130 (US) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)