(19)

(11)

EP 1 108 287 A1

(12)

(43) Date of publication: 20.06.2001 Bulletin 2001/25 (21) Application number: 99948064.3 (22) Date of filing: 26.08.1999

(51) International Patent Classification (IPC)7: H03M 1/12 (86) International application number: PCT/US9919/621 (87) International publication number: WO 0013/319 (09.03.2000 Gazette 2000/10)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 26.08.1998 US 97975 P (71) Applicant: The Johns Hopkins University Laurel, MD 20723-6099 (US)	(72) Inventor: PASCHALIDIS, Nikolaos P. Columbia, MD 21044 (US) (74) Representative: Patentanwälte Wenzel & Kalkoff  Grubesallee 26 22143 Hamburg 22143 Hamburg (DE)