(19)
(11) EP 1 109 815 A1

(12)

(43) Date of publication:
27.06.2001 Bulletin 2001/26

(21) Application number: 99903243.6

(22) Date of filing: 21.01.1999
(51) International Patent Classification (IPC)7C07D 491/044, A61K 31/44, A61K 31/55, C07D 495/04, C07D 221/16, C07D 471/04, C07D 401/06
// (C07D491/044, 313:00), C07D221:00,(C07D495/04, 337:00), C07D221:00,(C07D471/04, 223:00), C07D221:00
(86) International application number:
PCT/US9901/235
(87) International publication number:
WO 0014/089 (16.03.2000 Gazette 2000/11)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

(30) Priority: 04.09.1998 US 146827

(71) Applicants:
  • Millennium Pharmaceuticals, Inc.
    Cambridge,Massachusetts 02139 (US)
  • KYOWA HAKKO KOGYO CO., LTD.
    Chiyoda-ku,Tokyo 100 (JP)

(72) Inventors:
  • LULY, Jay, R.
    Wellesley, MA 02481 (US)
  • NAKASATO, Yoshisuke
    Sunto-gun,Shizuoka 411 (JP)
  • OHSHIMA, Etsuo
    Sunto-gun,Shizuoka 411 (JP)

(74) Representative: Roques, Sarah Elizabeth 
J.A. Kemp & Co.14 South SquareGray's Inn
London WC1R 5JJ
London WC1R 5JJ (GB)

   


(54) CHEMOKINE RECEPTOR ANTAGONISTS AND METHODS OF USE THEREFOR