(19)

(11)

EP 1 109 829 A1

(12)

(43) Date of publication: 27.06.2001 Bulletin 2001/26 (21) Application number: 99946639.4 (22) Date of filing: 30.08.1999

(51) International Patent Classification (IPC)7: C07K 14/47, C07H 21/04, C12N 1/21, C12N 15/00, C12P 21/00 (86) International application number: PCT/US9919/436 (87) International publication number: WO 0012/551 (09.03.2000 Gazette 2000/10)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 01.09.1998 US 98766 P (71) Applicant: Eli Lilly & Company Indianapolis,Indiana 46285 (US)	(72) Inventor: EDMONDS, Brian, Taylor Carmel, IN 46032 (US) (74) Representative: Denholm, Anna Marie  Eli Lilly and Company Limited,Lilli Research Centre,Erl Wood Manor WindleshamSurrey GU20 6PH WindleshamSurrey GU20 6PH (GB)