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(11)

EP 1 109 833 A2

(12)

(88) Date of publication A3: 23.11.2000 (43) Date of publication: 27.06.2001 Bulletin 2001/26 (21) Application number: 99945592.6 (22) Date of filing: 08.09.1999

(51) International Patent Classification (IPC)7: C07K 16/18, C07K 16/22, C07K 16/28, A61K 39/395, G01N 33/53, G01N 33/574, C12Q 1/68, C12N 5/16, C12N 15/11, C12N 15/12, C12N 15/13, C12N 15/63 (86) International application number: PCT/US9920/594 (87) International publication number: WO 0015/666 (23.03.2000 Gazette 2000/12)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 10.09.1998 US 99803 P 10.09.1998 WO PCT/US98/18824 (71) Applicant: Genentech, Inc. South San Francisco, CA 94080-4990 (US)

(72) Inventors: GODDARD, Audrey San Francisco, CA 94131 (US) GURNEY, Austin, L. Belmont, CA 94002 (US) HILLAN, Kenneth, J. San Francisco, CA 94114 (US) ROY, Margaret, Ann San Francisco, CA 94123 (US) WOOD, William, I. Hillsborough, CA 94010 (US) BOTSTEIN, David Belmont, CA 94002 (US) (74) Representative: Denison, Christopher Marcus et al Mewburn EllisYork House23 Kingsway GB-London WC2B 6HP GB-London WC2B 6HP (GB)