(19)

(11)

EP 1 109 905 A1

(12)

(43) Date of publication: 27.06.2001 Bulletin 2001/26 (21) Application number: 99946314.4 (22) Date of filing: 10.09.1999

(51) International Patent Classification (IPC)7: C12N 15/12, C07K 14/47, C12N 15/63, C07K 16/18, C12Q 1/68, A61K 38/17, A61K 48/00 (86) International application number: PCT/GB9903/019 (87) International publication number: WO 0015/787 (23.03.2000 Gazette 2000/12)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 10.09.1998 SE 9803069 17.09.1998 US 100873 P (71) Applicant: CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS 28006 Madrid (ES)	(72) Inventors: ALONSO, Carlos Martinez E-28034 Madrid (ES) DOMINGO, David Garcia E-28002 Madrid (ES) GRANDIEN, Alf S-118 24 Stockholm (SE) LEONARDO, Esther E-28006 Madrid (ES) MARTINEZ, Pedro E-28016 Madrid (ES) (74) Representative: Elsy, David et al Withers & Rogers,Goldings House,2 Hays Lane London SE1 2HW London SE1 2HW (GB)