(19)

(11)

EP 1 109 910 A2

(12)

(88) Date of publication A3: 08.09.2000 (43) Date of publication: 27.06.2001 Bulletin 2001/26 (21) Application number: 99968680.1 (22) Date of filing: 07.09.1999

(51) International Patent Classification (IPC)7: C12N 15/29, C12N 15/53, C12N 15/82, C12Q 1/68, C07K 14/415, C12N 9/02 (86) International application number: PCT/US9920/420 (87) International publication number: WO 0014/239 (16.03.2000 Gazette 2000/11)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 08.09.1998 US 99501 P (71) Applicant: E.I. DU PONT DE NEMOURS AND COMPANY WilmingtonDelaware 19898 (US)	(72) Inventors: ALLEN, Stephen, M. Wilmington, DE 19810 (US) THORPE, Catherine, J. Cambridge CB4 1FY (GB) LU, Albert, L. Newark, DE 19702 (US) (74) Representative: Webber, Philip Michael  Frank B. Dehn & Co.,179 Queen Victoria Street London EC4V 4EL London EC4V 4EL (GB)