(19)

(11)

EP 1 109 911 A2

(12)

(88) Date of publication A3: 15.06.2000 (43) Date of publication: 27.06.2001 Bulletin 2001/26 (21) Application number: 99948076.7 (22) Date of filing: 31.08.1999

(51) International Patent Classification (IPC)7: C12N 15/31, C12N 15/66, C12N 15/63, C12N 1/21, C07K 14/31 (86) International application number: PCT/US9919/726 (87) International publication number: WO 0012/678 (09.03.2000 Gazette 2000/10)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 01.09.1998 US 98964 P (71) Applicant: Human Genome Sciences, Inc. Rockville, MD 20850 (US)	(72) Inventors: BAILEY, Camella, C. Washington, DC 20010 (US) CHOI, Gil, H. Rockville, MD 20850 (US) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)