(19)

(11)

EP 1 109 931 A1

(12)

(43) Date of publication: 27.06.2001 Bulletin 2001/26 (21) Application number: 99945460.6 (22) Date of filing: 02.09.1999

(51) International Patent Classification (IPC)7: C12Q 1/66, C12Q 1/00, C12P 21/06, C07H 21/04, G01N 33/53, G01N 33/567, G01N 33/573, G01N 33/58, G01N 33/60, G01N 33/531, G01N 33/533, G01N 21/00, G01N 21/76, G01N 21/75, G01N 31/00 (86) International application number: PCT/US9920/207 (87) International publication number: WO 0014/271 (16.03.2000 Gazette 2000/11)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 03.09.1998 US 99068 P 24.05.1999 US 135835 P (71) Applicant: LOMA LINDA UNIVERSITY Loma Linda, CA 92350 (US)	(72) Inventors: SZALAY, Aladar, A. Highland, CA 92346 (US) WANG, Yubao Loma Linda, CA 92354 (US) WANG-PRUSKI, Gefu Truro, Nova Scotia B2N 4L3 (CA) (74) Representative: Jorio, Paolo et al STUDIO TORTA S.r.l.,Via Viotti, 9 10121 Torino 10121 Torino (IT)