(19)

(11)

EP 1 112 071 A1

(12)

(43) Date of publication: 04.07.2001 Bulletin 2001/27 (21) Application number: 99907136.8 (22) Date of filing: 19.02.1999

(51) International Patent Classification (IPC)7: A61K 31/415, A61K 31/445, A61K 38/05, C07D 401/12, C07D 401/14, C07D 409/12, C07D 413/12 (86) International application number: PCT/US9903/525 (87) International publication number: WO 0010/565 (02.03.2000 Gazette 2000/09)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 18.08.1998 EP 98306622 18.08.1998 EP 98306621 19.08.1998 WO PCT/US00/17229 (71) Applicant: Eli Lilly & Company Indianapolis,Indiana 46285 (US)

(72) Inventors: DODGE, Jeffrey Alan Indianapolis, IN 46236 (US) HAUSER, Kenneth Lee Greencastle, IN 46135 (US) HEIMAN, Mark Louis Indianapolis, IN 46250 (US) JONES, Scott Alan Indianapolis, IN 46227 (US) ALT, Charles Arthur Greenwood, IN 46143 (US) BRYANT, Henry Uhlman Indianapolis, IN 46250 (US) COHEN, Jeffrey Daniel Indianapolis, IN 46260 (US) COPP, James Densmore Greenwood, IN 46143 (US) GRITTON, William Harlan Indianapolis, IN 46077 (US) JUNGHEIM, Louis Nickolaus Indianapolis, IN 46240 (US) LUGAR, Charles Willis, III McCordsville, IN 46055 (US) MUEHL, Brian Stephen Indianapolis, IN 46217 (US) PALKOWITZ, AlanDavid Carmel, IN 46032 (US) RATZ, Andrew Michael Greenwood, IN 46142 (US) RHODES, Gary Anthony Indianapolis, 46236 (US) ROBEY, Roger Lewis Greenwood, IN 46143 (US) SHEPHERD, Timothy Alan Indianapolis, IN 46227 (US) THRASHER, Kenneth Jeff Indianapolis, IN 46217 (US) TRANKLE, William George Southport, IN 46227 (US) (74) Representative: Pritchard, Judith  Lilly Research Centre,Erl Wood Manor Windlesham,Surrey GU20 6PH Windlesham,Surrey GU20 6PH (GB)