(19)
(11) EP 1 112 072 A2

(12)

(88) Date of publication A3:
29.06.2000

(43) Date of publication:
04.07.2001 Bulletin 2001/27

(21) Application number: 99945325.1

(22) Date of filing: 27.08.1999
(51) International Patent Classification (IPC)7A61K 31/4164, A61K 31/4166, A61K 31/421, A61K 31/426, C12N 15/85, C12N 5/10, C12Q 1/68, C07D 233/94, A61P 37/06
(86) International application number:
PCT/US9919/862
(87) International publication number:
WO 0012/175 (09.03.2000 Gazette 2000/10)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
Designated Extension States:
AL LT LV MK RO SI

(30) Priority: 31.08.1998 US 144311
25.08.1999 US 382960

(71) Applicants:
  • Sentron Medical, Inc.
    Cincinnati, OH 45242 (US)
  • The Government of the United States of America, as represented by the Secretary Department of Health and Human Services
    Rockville, MD 20852-3804 (US)

(72) Inventors:
  • KOHN, Leonard, D.
    Bethesda, MD 20814 (US)
  • CURLEY, Robert, W.
    Columbus, OH 43214 (US)
  • RICE, John, M.
    West Chester, OH 45069 (US)

(74) Representative: Carpmael, John William Maurice et al
CARPMAELS & RANSFORD43 Bloomsbury Square
London, WC1A 2RA
London, WC1A 2RA (GB)

   


(54) METHIMAZOLE DERIVATIVES AND TAUTOMERIC CYCLIC THIONES TO TREAT AUTOIMMUNE DISEASES