(19)

(11)

EP 1 112 358 A2

(12)

(88) Date of publication A3: 25.05.2000 (43) Date of publication: 04.07.2001 Bulletin 2001/27 (21) Application number: 99943188.5 (22) Date of filing: 08.09.1999

(51) International Patent Classification (IPC)7: C12N 15/12, C12N 15/62, C07K 14/47, C07K 14/475, C12Q 1/68, A61K 38/17, A61K 38/18 (86) International application number: PCT/IL9900/485 (87) International publication number: WO 0015/788 (23.03.2000 Gazette 2000/12)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 11.09.1998 IL 12618198 (71) Applicant: Gardino Investment N.V. Curacao (NA)	(72) Inventor: MOROZ, Chaya 69393 Tel-Aviv (IL) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)