(19)

(11)

EP 1 112 359 A2

(12)

(88) Date of publication A3: 30.11.2000 (43) Date of publication: 04.07.2001 Bulletin 2001/27 (21) Application number: 99944033.2 (22) Date of filing: 01.09.1999

(51) International Patent Classification (IPC)7: C12N 15/12, C07K 14/705, C12N 1/19, C12N 15/67, C12N 15/63, C12N 15/62, C07K 14/72, C07K 14/47, C12Q 1/02, C07K 14/395, C12N 15/31 (86) International application number: PCT/US9920/011 (87) International publication number: WO 0012/704 (09.03.2000 Gazette 2000/10)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 01.09.1998 US 98704 P (71) Applicants: BASF Aktiengesellschaft 67063 Ludwigshafen (DE) Pausch, Mark Henry Princeton, NJ 08543-0400 (US) Lai, Margaret Princeton, NJ 08543-0400 (US) Silverman, Sanford Princeton, NJ 08543-0400 (US) Birsan, Camelia Princeton, NJ 08543-0400 (US) Baumbach, William Princeton, NJ 08543-0400 (US) Tseng, Eugene Princeton, NJ 08543-0400 (US) Kajkowski, Eileen Marie Princeton, NJ 08543-8000 (US) Ozenberger, Bradley Alton Princeton, NJ 08543-8000 (US)

(72) Inventors: PAUSCH, Mark Henry Clarksville, NJ 08543-0400 (US) LAI, Margaret,American Cyanamid Company Clarksville, NJ 08543-0400 (US) SILVERMAN, Sanford,American Cyanamid Company Clarksville, NJ 08543-0400 (US) BIRSAN, Camelia,American Cyanamid Company Clarksville, NJ 08543-0400 (US) BAUMBACH, William,American Cyanamid Company Clarksville, NJ 08543-0400 (US) TSENG, Eugene,American Cyanamid Company Clarksville, NJ 08543-0400 (US) KAJKOWSKI, Eileen Marie Princeton, NJ 08543-8000 (US) OZENBERGER, Bradley Alton Princeton, NJ 08543-8000 (US) (74) Representative: Fitzner, Uwe, Dr.  Dres. Fitzner & MünchRechts- und PatentanwälteLintorfer Strasse 10 40878 Ratingen 40878 Ratingen (DE)