(19)

(11)

EP 1 112 361 A2

(12)

(88) Date of publication A3: 21.09.2000 (43) Date of publication: 04.07.2001 Bulletin 2001/27 (21) Application number: 99946891.1 (22) Date of filing: 13.09.1999

(51) International Patent Classification (IPC)7: C12N 15/12, C07K 14/47, A61K 38/17, G01N 33/50, C12Q 1/68, C07K 16/18, A61K 31/70 (86) International application number: PCT/US9920/944 (87) International publication number: WO 0015/792 (23.03.2000 Gazette 2000/12)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 14.09.1998 US 100262 P 14.09.1998 WO PCT/US98/19177 (71) Applicant: Genentech, Inc. South San Francisco, CA 94080-4990 (US)

(72) Inventors: FONG, Sherman Alameda, CA 94502 (US) GERRITSEN, Mary, E. San Mateo, CA 94402 (US) GODDARD, Audrey San Francisco, CA 94131 (US) GURNEY, Austin, L. Belmont, CA 94002 (US) HILLAN, Kenneth, J. San Francisco, CA 94114 (US) WILLIAMS, P., Mickey Half Moon Bay, CA 94019 (US) WOOD, William, I. Hillsborough, CA 94010 (US) (74) Representative: Denison, Christopher Marcus et al Mewburn EllisYork House23 Kingsway GB-London WC2B 6HP GB-London WC2B 6HP (GB)