(19)

(11)

EP 1 112 364 A2

(12)

(88) Date of publication A3: 08.06.2000 (43) Date of publication: 04.07.2001 Bulletin 2001/27 (21) Application number: 99948205.2 (22) Date of filing: 14.09.1999

(51) International Patent Classification (IPC)7: C12N 15/12, C07K 14/47, C12N 15/62, C07K 16/18, A61K 38/17, G01N 33/68 (86) International application number: PCT/US9921/023 (87) International publication number: WO 0015/659 (23.03.2000 Gazette 2000/12)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 16.09.1998 US 154444 (71) Applicant: ZymoGenetics Seattle, WA 98102 (US)	(72) Inventors: SHEPPARD, Paul, O. Redmond, WA 98053 (US) FOLEY, Kevin, P. Seattle, WA 98102 (US) (74) Representative: Schlich, George William et al Mathys & Squire100 Gray's Inn Road London WC1X 8AL London WC1X 8AL (GB)