(19)

(11)

EP 1 114 029 A1

(12)

(43) Date of publication: 11.07.2001 Bulletin 2001/28 (21) Application number: 99949512.0 (22) Date of filing: 13.09.1999

(51) International Patent Classification (IPC)7: C07D 213/60, C07D 237/08, C07D 239/26, C07D 207/267, C07C 321/28, C07C 235/46, A61K 31/44, A61K 31/50, A61K 31/165 (86) International application number: PCT/SE9901/600 (87) International publication number: WO 0015/614 (23.03.2000 Gazette 2000/12)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 14.09.1998 SE 9803107 (71) Applicant: AstraZeneca AB 151 85 Södertälje (SE)	(72) Inventors: CHESHIRE, David Loughborough,Leics LE11 5RH (GB) CLADINGBOEL, David Loughborough,Leics LE11 5RH (GB) HIRST, Simon Loughborough,Leics LE11 5RH (GB) STOCKS, Michael Loughborough,Leics LE11 5RH (GB)