(19)

(11)

EP 1 115 419 A2

(12)

(88) Date of publication A3: 22.06.2000 (43) Date of publication: 18.07.2001 Bulletin 2001/29 (21) Application number: 99948094.0 (22) Date of filing: 31.08.1999

(51) International Patent Classification (IPC)7: A61K 38/16, A61K 31/65, A61K 31/43, A61K 31/545, A61K 31/47, A61K 31/42 (86) International application number: PCT/US9920/052 (87) International publication number: WO 0012/048 (09.03.2000 Gazette 2000/10)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 01.09.1998 US 98738 P (71) Applicant: MERCK & CO., INC. Rahway, New Jersey 07065 (US)	(72) Inventors: DORSO, Karen, L. Rahway, NJ 07065 (US) GILL, Charles, J. Rahway, NJ 07065 (US) JACKSON, Jesse, J. Rahway, NJ 07065 (US) KOHLER, Joyce Rahway, NJ 07065 (US) SILVER, Lynn, L. Rahway, NJ 07065 (US) (74) Representative: Hiscock, Ian James  European Patent Department,Merck & Co., Inc.,Terlings Park,Eastwick Road Harlow,Essex CM20 2QR Harlow,Essex CM20 2QR (GB)