(19)

(11)

EP 1 115 706 A1

(12)

(43) Date of publication: 18.07.2001 Bulletin 2001/29 (21) Application number: 99969714.7 (22) Date of filing: 17.09.1999

(51) International Patent Classification (IPC)7: C07D 213/30, A61K 31/44 (86) International application number: PCT/SE9901/632 (87) International publication number: WO 0018/730 (06.04.2000 Gazette 2000/14)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 25.09.1998 SE 9803280 (71) Applicant: AstraZeneca AB 151 85 Södertälje (SE)	(72) Inventors: CHESHIRE, DavidAstraZeneca R&D Charnwood Leics LE11 5RH (GB) STOCKS, MichaelAstraZeneca R&D Charnwood Leics LE11 5RH (GB)