(19)

(11)

EP 1 115 867 A1

(12)

(43) Date of publication: 18.07.2001 Bulletin 2001/29 (21) Application number: 99949626.8 (22) Date of filing: 20.09.1999

(51) International Patent Classification (IPC)7: C12N 15/24, C07K 14/54, C12Q 1/68, C07K 16/24, C12N 5/10, G01N 33/68, C12N 5/08 (86) International application number: PCT/US9920/871 (87) International publication number: WO 0017/362 (30.03.2000 Gazette 2000/13)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 21.09.1998 US 157749 27.04.1999 US 131298 P (71) Applicant: SCHERING CORPORATION Kenilworth,New Jersey 07033-0530 (US)	(72) Inventor: BAZAN, J., Fernando Menlo Park, CA 94025 (US) (74) Representative: Ritter, Stephen David et al Mathys & Squire100 Gray's Inn Road London WC1X 8AL London WC1X 8AL (GB)