(19)

(11)

EP 1 115 875 A1

(12)

(43) Date of publication: 18.07.2001 Bulletin 2001/29 (21) Application number: 99969446.6 (22) Date of filing: 24.09.1999

(51) International Patent Classification (IPC)7: C12N 15/57, C12N 9/52, C07K 16/40, A01K 67/027, A61K 38/48, A61P 37/06 (86) International application number: PCT/US9922/362 (87) International publication number: WO 0017/370 (30.03.2000 Gazette 2000/13)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 24.09.1998 US 101736 P 31.03.1999 US 283094 (71) Applicants: REGENTS OF THE UNIVERSITY OF MINNESOTA Minneapolis, MN 55455-2070 (US) American Cynamid Company Madison, NJ 07940 (US)	(72) Inventors: HOSTETTER, Margaret K. New Haven, CT 06511 (US) FINKEL, David J. Minneapolis, MN 55414 (US) CHENG, Qi Plymouth, MN 55442 (US) GREEN, Bruce, A. Pittsford, NY 14534 (US) MASI, Amy, W. Caledonia, NY 14423 (US) (74) Representative: Perry, Robert Edward et al GILL JENNINGS & EVERYBroadgate House7 Eldon Street London EC2M 7LH London EC2M 7LH (GB)