(19)
(11) EP 1 115 880 A2

(12)

(88) Date of publication A3:
08.09.2000

(43) Date of publication:
18.07.2001 Bulletin 2001/29

(21) Application number: 99954648.4

(22) Date of filing: 22.09.1999
(51) International Patent Classification (IPC)7C12N 15/86, C12N 7/01, C12N 5/10
(86) International application number:
PCT/US9922/052
(87) International publication number:
WO 0017/377 (30.03.2000 Gazette 2000/13)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
Designated Extension States:
AL LT LV MK RO SI

(30) Priority: 22.09.1998 US 101507 P

(71) Applicants:
  • University of Florida
    Gainesville,Florida 32611-5500 (US)
  • THE JOHNS HOPKINS UNIVERSITY
    Baltimore, MD 21205 (US)

(72) Inventors:
  • BYRNE, Barry, J.-Dept. of Pediatrics and Pathology
    Baltimore, MD 21205 (US)
  • CONWAY, James, E.
    Baltimore, MD 21205 (US)
  • HAYWARD, Gary, S.
    Baltimore, MD 21205 (US)
  • MUZYCZKA, Nicholas
    Gainesville, FL 32608 (US)
  • ZOLOTUKHIN, Sergei-University of Florida
    P.O. Box 100266,Gainesville, FL 32611 (US)

(74) Representative: Glawe, Delfs, Moll & Partner 
PatentanwälteRothenbaumchaussee 58
20148 Hamburg
20148 Hamburg (DE)

   


(54) METHODS FOR LARGE-SCALE PRODUCTION OF RECOMBINANT AAV VECTORS