(19)

(11)

EP 1 117 405 A2

(12)

(88) Date of publication A3: 06.07.2000 (43) Date of publication: 25.07.2001 Bulletin 2001/30 (21) Application number: 99949707.6 (22) Date of filing: 06.10.1999

(51) International Patent Classification (IPC)7: A61K 31/445, A61K 45/06, A61P 11/06 // (A61K31/445, 31:00) (86) International application number: PCT/US9921/437 (87) International publication number: WO 0021/512 (20.04.2000 Gazette 2000/16)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 09.10.1998 US 169608 (71) Applicant: SCHERING CORPORATION Kenilworth,New Jersey 07033-0530 (US)	(72) Inventors: ASLANIAN, Robert, G. Rockaway, NJ 07866 (US) PIWINSKI, John, J. Clinton Township, NJ 08833 (US) (74) Representative: Ritter, Stephen David et al Mathys & Squire100 Gray's Inn Road London WC1X 8AL London WC1X 8AL (GB)