(19)

(11)

EP 1 117 764 A1

(12)

(43) Date of publication: 25.07.2001 Bulletin 2001/30 (21) Application number: 99921665.8 (22) Date of filing: 05.05.1999

(51) International Patent Classification (IPC)7: C12N 5/06 // C12N5:22 (86) International application number: PCT/US9909/784 (87) International publication number: WO 0012/682 (09.03.2000 Gazette 2000/10)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 01.09.1998 US 98712 P (71) Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION Madison, WI 53507-7365 (US)	(72) Inventor: THOMSON, James, A. 1223 Capital CourtMadison, WI 53715 (US) (74) Representative: Ellis-Jones, Patrick George Armine  J.A. KEMP & CO.14 South SquareGray's Inn London WC1R 5JJ London WC1R 5JJ (GB)