(19)

(11)

EP 1 117 768 A1

(12)

(43) Date of publication: 25.07.2001 Bulletin 2001/30 (21) Application number: 99938479.5 (22) Date of filing: 12.08.1999

(51) International Patent Classification (IPC)7: C12N 9/16, A61K 38/46 (86) International application number: PCT/IB9901/484 (87) International publication number: WO 0009/672 (24.02.2000 Gazette 2000/08)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 13.08.1998 US 96374 P (71) Applicant: Johnson & Johnson Research Pty Limited Eveleigh, NSW 1430 (AU)	(72) Inventors: SUN, Lun-Quan Ryde, NSW 2112 (AU) CAIRNS, Murray, J. Woy Woy, NSW 2256 (AU) (74) Representative: Mercer, Christopher Paul et al Carpmaels & Ransford43, Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)