(19)

(11)

EP 1 117 777 A2

(12)

(88) Date of publication A3: 26.10.2000 (43) Date of publication: 25.07.2001 Bulletin 2001/30 (21) Application number: 99969739.4 (22) Date of filing: 28.09.1999

(51) International Patent Classification (IPC)7: C12N 15/10, C12N 15/11, C12N 5/10, C12N 7/04, A61K 39/21, C07B 61/00, G06F 19/00, B01J 19/00 // (C12N15/12, 15:55, 15:49) (86) International application number: PCT/US9922/588 (87) International publication number: WO 0018/906 (06.04.2000 Gazette 2000/14)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 29.09.1998 US 102362 P 29.01.1999 US 117729 P 05.02.1999 US 118813 P 24.06.1999 US 141049 P (71) Applicant: Maxygen, Inc. Redwood City, CA 94063 (US)	(72) Inventors: PATTEN, Phillip, A. Mountain View, CA 94040 (US) LIU, Lu Redwood City, CA 94056 (US) STEMMER, Willem, P., C. Los Gatos, CA 95030 (US) (74) Representative: Ryberg, Lise Abildgaard et al Maxygen ApS,Agern Alle 1 2970 Hoersholm 2970 Hoersholm (DK)