(19)

(11)

EP 1 117 793 A2

(12)

(88) Date of publication A3: 28.09.2000 (43) Date of publication: 25.07.2001 Bulletin 2001/30 (21) Application number: 99953037.1 (22) Date of filing: 01.10.1999

(51) International Patent Classification (IPC)7: C12N 15/12, C07K 14/47, C07K 16/18, A61K 38/17 (86) International application number: PCT/US9922/970 (87) International publication number: WO 0018/796 (06.04.2000 Gazette 2000/14)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 01.10.1998 US 164740 (71) Applicant: ZymoGenetics, Inc. Seattle, WA 98102 (US)	(72) Inventors: LOK, Si Seattle, WA 98107 (US) SHEPPARD, Paul, O. Redmond, WA 98053 (US) (74) Representative: Schlich, George William et al Mathys & Squire100 Gray's Inn Road London WC1X 8AL London WC1X 8AL (GB)